Daughters K, Cinat M, Waxman K
Department of Surgery, University of California Irvine, Orange.
Am Surg. 1994 Oct;60(10):728-32.
Amrinone is a noncatecholamine inotropic agent used clinically in the management of heart failure. The purpose of this study was to determine if intravenous (i.v.) infusion of amrinone has beneficial effects during resuscitation from experimental hemorrhagic shock. Effectiveness was defined as significantly improved survival rate. Mean arterial pressure (MAP) and tissue oxygen tension (pO2) were measured to assess the physiologic effects of amrinone. Two separate randomized and blinded survival trials were conducted. In each trial, rats were randomly assigned to either a control group (n = 10) or an experimental group (n = 10). All animals were bled 27 ml/kg over 2 minutes and maintained in shock for 45 minutes before resuscitation. Resuscitation in placebo (control) animals was with 54 ml/kg (2 times the hemorrhage volume) Lactated Ringer's solution over 1 hour, whereas resuscitation in drug-treated animals was with a 0.75 mg/kg bolus amrinone over 3 minutes followed by 54 ml/kg Lactated Ringer's solution and 5 ug/kg/min infusion over 1 hour. Results were that resuscitation with amrinone significantly increased MAP, tissue pO2, and survival over resuscitation with Lactated Ringer's alone (P < 0.05). In both trials, survival rates increased by more than 66 per cent in the amrinone groups.
氨力农是一种非儿茶酚胺类强心剂，临床上用于治疗心力衰竭。本研究的目的是确定静脉输注氨力农在实验性失血性休克复苏过程中是否具有有益作用。有效性定义为存活率显著提高。测量平均动脉压（MAP）和组织氧分压（pO2）以评估氨力农的生理作用。进行了两项独立的随机双盲生存试验。在每项试验中，大鼠被随机分为对照组（n = 10）或实验组（n = 10）。所有动物在2分钟内失血27 ml/kg，并在复苏前维持休克状态45分钟。安慰剂（对照）组动物用54 ml/kg（失血量的2倍）乳酸林格氏液在1小时内进行复苏，而药物治疗组动物先用0.75 mg/kg氨力农静脉推注3分钟，然后用54 ml/kg乳酸林格氏液并在1小时内以5 μg/kg/min的速度输注。结果表明，与单独使用乳酸林格氏液复苏相比，氨力农复苏显著提高了MAP、组织pO2和存活率（P < 0.05）。在两项试验中，氨力农组的存活率均提高了66%以上。
