脂蛋白脂肪酶的羧基末端结构域通过低密度脂蛋白受体相关蛋白/α2-巨球蛋白受体诱导正常极低密度脂蛋白的细胞分解代谢。 - Suppr | 超能文献

The carboxy-terminal domain of lipoprotein lipase induces cellular catabolism of normal very low density lipoproteins via the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.

作者信息

Chappell D A, Inoue I, Fry G L, Pladet M W, Iverius P H, Lalouel J M, Strickland D K

机构信息

Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242.

出版信息

Ann N Y Acad Sci. 1994 Sep 10;737:434-8. doi: 10.1111/j.1749-6632.1994.tb44333.x.

DOI:10.1111/j.1749-6632.1994.tb44333.x

Abstract

摘要

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1

The carboxy-terminal domain of lipoprotein lipase induces cellular catabolism of normal very low density lipoproteins via the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.脂蛋白脂肪酶的羧基末端结构域通过低密度脂蛋白受体相关蛋白/α2-巨球蛋白受体诱导正常极低密度脂蛋白的细胞分解代谢。

Ann N Y Acad Sci. 1994 Sep 10;737:434-8. doi: 10.1111/j.1749-6632.1994.tb44333.x.

2

Cellular catabolism of normal very low density lipoproteins via the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor is induced by the C-terminal domain of lipoprotein lipase.正常极低密度脂蛋白通过低密度脂蛋白受体相关蛋白/α2-巨球蛋白受体的细胞分解代谢由脂蛋白脂肪酶的C末端结构域诱导。

J Biol Chem. 1994 Jul 8;269(27):18001-6.

3

Analysis of ligand binding to the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Evidence that lipoprotein lipase and the carboxyl-terminal domain of the receptor-associated protein bind to the same site.配体与α2-巨球蛋白受体/低密度脂蛋白受体相关蛋白结合的分析。脂蛋白脂肪酶和受体相关蛋白的羧基末端结构域结合至同一位点的证据。

J Biol Chem. 1995 Oct 6;270(40):23713-9. doi: 10.1074/jbc.270.40.23713.

4

Lipoprotein lipase binds to low density lipoprotein receptors and induces receptor-mediated catabolism of very low density lipoproteins in vitro.脂蛋白脂肪酶与低密度脂蛋白受体结合，并在体外诱导极低密度脂蛋白的受体介导分解代谢。

J Biol Chem. 1996 Jul 19;271(29):17073-80. doi: 10.1074/jbc.271.29.17073.

5

Lipoprotein lipase induces catabolism of normal triglyceride-rich lipoproteins via the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor in vitro. A process facilitated by cell-surface proteoglycans.脂蛋白脂肪酶在体外通过低密度脂蛋白受体相关蛋白/α2-巨球蛋白受体诱导富含甘油三酯的正常脂蛋白的分解代谢。这一过程由细胞表面蛋白聚糖促进。

J Biol Chem. 1993 Jul 5;268(19):14168-75.

6

The carboxyl-terminal domain of lipoprotein lipase binds to the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor (LRP) and mediates binding of normal very low density lipoproteins to LRP.脂蛋白脂肪酶的羧基末端结构域与低密度脂蛋白受体相关蛋白/α2-巨球蛋白受体（LRP）结合，并介导正常极低密度脂蛋白与LRP的结合。

J Biol Chem. 1994 Mar 25;269(12):8653-8.

7

A carboxyl-terminal fragment of lipoprotein lipase binds to the low density lipoprotein receptor-related protein and inhibits lipase-mediated uptake of lipoprotein in cells.脂蛋白脂肪酶的羧基末端片段与低密度脂蛋白受体相关蛋白结合，并抑制脂肪酶介导的细胞内脂蛋白摄取。

J Biol Chem. 1994 Dec 16;269(50):31747-55.

8

The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds lipoprotein lipase and beta-migrating very low density lipoprotein associated with the lipase.α2-巨球蛋白受体/低密度脂蛋白受体相关蛋白结合脂蛋白脂肪酶以及与该脂肪酶相关的β-迁移极低密度脂蛋白。

J Biol Chem. 1993 Jul 15;268(20):15048-55.

9

The multiligand alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein (alpha 2MR/LRP). Binding and endocytosis of fluid phase and membrane-associated ligands.

Ann N Y Acad Sci. 1994 Sep 10;737:20-38. doi: 10.1111/j.1749-6632.1994.tb44299.x.

10

Segments in the C-terminal folding domain of lipoprotein lipase important for binding to the low density lipoprotein receptor-related protein and to heparan sulfate proteoglycans.脂蛋白脂肪酶C端折叠结构域中对与低密度脂蛋白受体相关蛋白及硫酸乙酰肝素蛋白聚糖结合很重要的片段。

J Biol Chem. 1997 Feb 28;272(9):5821-7. doi: 10.1074/jbc.272.9.5821.

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Lipoprotein lipase bound to apolipoprotein B lipoproteins accelerates clearance of postprandial lipoproteins in humans.与载脂蛋白B脂蛋白结合的脂蛋白脂肪酶可加速人体餐后脂蛋白的清除。

Arterioscler Thromb Vasc Biol. 2006 Apr;26(4):891-6. doi: 10.1161/01.ATV.0000203512.01007.3d. Epub 2006 Jan 12.

2

Lipoprotein lipase- and hepatic triglyceride lipase- promoted very low density lipoprotein degradation proceeds via an apolipoprotein E-dependent mechanism.脂蛋白脂肪酶和肝甘油三酯脂肪酶促进的极低密度脂蛋白降解通过载脂蛋白E依赖性机制进行。

J Lipid Res. 2000 Nov;41(11):1858-71.