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Both pro-uPA and uPA: PAI-1 complex bind to the alpha 2-macroglobulin receptor/LDL receptor-related protein. Evidence for multiple independent contacts between the ligands and receptor.

作者信息

Nykjaer A, Kjøller L, Cohen R L, Lawrence D A, Gliemann J, Andreasen P A

机构信息

Department of Medical Biochemistry, University of Aarhus, Denmark.

出版信息

Ann N Y Acad Sci. 1994 Sep 10;737:483-5. doi: 10.1111/j.1749-6632.1994.tb44346.x.

DOI:10.1111/j.1749-6632.1994.tb44346.x
PMID:7944152
Abstract
摘要

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Both pro-uPA and uPA: PAI-1 complex bind to the alpha 2-macroglobulin receptor/LDL receptor-related protein. Evidence for multiple independent contacts between the ligands and receptor.
Ann N Y Acad Sci. 1994 Sep 10;737:483-5. doi: 10.1111/j.1749-6632.1994.tb44346.x.
2
Regions involved in binding of urokinase-type-1 inhibitor complex and pro-urokinase to the endocytic alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Evidence that the urokinase receptor protects pro-urokinase against binding to the endocytic receptor.参与尿激酶-1型抑制剂复合物和尿激酶原与内吞性α2-巨球蛋白受体/低密度脂蛋白受体相关蛋白结合的区域。尿激酶受体保护尿激酶原不与内吞性受体结合的证据。
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Biochem J. 1998 Jan 1;329 ( Pt 1)(Pt 1):55-63. doi: 10.1042/bj3290055.
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Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes.纯化的α2-巨球蛋白受体/低密度脂蛋白受体相关蛋白结合尿激酶-纤溶酶原激活物抑制剂1型复合物。α2-巨球蛋白受体介导尿激酶受体结合复合物细胞内降解的证据。
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Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor mediates cellular uptake of pro-urokinase.低密度脂蛋白受体相关蛋白/α2-巨球蛋白受体介导尿激酶原的细胞摄取。
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Degradation of urokinase plasminogen activator (UPA) in endometrial stromal cells requires both the UPA receptor and the low-density lipoprotein receptor-related protein/alpha2-macroglobulin receptor.子宫内膜基质细胞中尿激酶型纤溶酶原激活剂(UPA)的降解既需要UPA受体,也需要低密度脂蛋白受体相关蛋白/α2-巨球蛋白受体。
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Binding areas of urokinase-type plasminogen activator-plasminogen activator inhibitor-1 complex for endocytosis receptors of the low-density lipoprotein receptor family, determined by site-directed mutagenesis.通过定点诱变确定尿激酶型纤溶酶原激活剂-纤溶酶原激活剂抑制剂-1复合物与低密度脂蛋白受体家族内吞作用受体的结合区域。
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Analysis of ligand binding to the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Evidence that lipoprotein lipase and the carboxyl-terminal domain of the receptor-associated protein bind to the same site.配体与α2-巨球蛋白受体/低密度脂蛋白受体相关蛋白结合的分析。脂蛋白脂肪酶和受体相关蛋白的羧基末端结构域结合至同一位点的证据。
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