Yaoita H, Hertz K C, Katz S I
J Invest Dermatol. 1976 Dec;67(6):691-5. doi: 10.1111/1523-1747.ep12598569.
Using immunoelectronmicroscopic techniques, we have demonstrated three distincet patterns of IgA deposition in the skin of patients with dermatitis herpetiforms. The least common of these patterns is the localization of reaction products to the lamina lucida. As this is the location of the immunoreactants in bullous pemphigoid and herpes gestationis and because the ultrastructural findings in our patient's early lesional skin differ from those usually seen in patients with dermatitis herpetiformis, we herein detail this patient's clinical, histologic, immunologic, and ultrastructural findings. The most prominent findings are (1) IgA deposition in the lamina lucida, (2) vesicle formation between basal lamina and the basal cells, and (3) fibrin-like material in the epidermis with showering into the dermis.
运用免疫电子显微镜技术，我们在疱疹样皮炎患者的皮肤中证实了三种不同的IgA沉积模式。这些模式中最不常见的是反应产物定位于透明板。由于这是大疱性类天疱疮和妊娠疱疹中免疫反应物的位置，且我们患者早期皮损皮肤的超微结构发现与疱疹样皮炎患者通常所见不同，我们在此详细阐述该患者的临床、组织学、免疫学和超微结构发现。最显著的发现是：（1）IgA沉积于透明板；（2）在基膜和基底细胞之间形成水疱；（3）表皮中有纤维蛋白样物质并呈阵雨状进入真皮。
