Yamasaki Y, Hashimoto T, Nishikawa T
Acta Derm Venereol. 1982;62(5):401-5.
Ultrastructural localization of bound IgA in the skin of a patient suffering from dermatitis herpetiformis with linear IgA deposition at the dermo-epidermal junction was studied using the horseradish peroxidase labelled antibody method. The reaction products were observed as electron-dense materials, not only immediately below the cytomembrane of the basal cells but also in the uppermost dermis just below the basal lamina. The major portion of the lamina lucida was free of the reaction products. These findings suggest a diversity in the mode of IgA deposition and the possibility of the presence of different antigens in the basement membrane zone, to which IgA class antibodies may be bound respectively.
采用辣根过氧化物酶标记抗体法，对1例疱疹样皮炎患者皮肤进行研究，该患者在真皮 - 表皮交界处有线性IgA沉积。反应产物表现为电子致密物质，不仅位于基底细胞细胞膜下方紧邻处，也位于基膜下方最上层真皮中。透明层的大部分区域没有反应产物。这些发现提示IgA沉积方式具有多样性，且基底膜带可能存在不同抗原，IgA类抗体可能分别与之结合。
