Kawasaki S, Nagai K, Maruyama S, Murakami M, Yoshizane K, Morokoshi Y, Kawai K, Yamamoto M, Soda M
Dept. of Surgery, Himeji St. Mary's Hospital.
Gan To Kagaku Ryoho. 1994 Sep;21(13):2256-9.
Regional chemotherapy was given 16 unresectable gastric cancer patients. Two types of the chemotherapy, intraperitoneal (IP) and intraaortic (IA) administration, were carried out. The control group was comprised of 17 patients. The response of the chemotherapy for primary tumor was 36.4% in the IP group and 20% in the IA one. Among these patients, 2 of 11 in IP and 1 of 5 in IA were able to resect the primary tumor. The 50% survival time of IP, IA and control was 347, 227 and 78 days, respectively. One-year survival rates of IP, IA and control were 68%, 29% and 0%, respectively. IP showed a significantly longer survival rate than controls (p < 0.001). All but one patient was able to stay at home. Intraperitoneal chemotherapy showed both local and systemic effects in unresectable gastric cancer.
对16例无法切除的胃癌患者进行了区域化疗。采用了两种化疗方式，即腹腔内（IP）给药和主动脉内（IA）给药。对照组由17例患者组成。IP组对原发性肿瘤的化疗有效率为36.4%，IA组为20%。在这些患者中，IP组11例中有2例、IA组5例中有1例能够切除原发性肿瘤。IP组、IA组和对照组的50%生存时间分别为347天、227天和78天。IP组、IA组和对照组的1年生存率分别为68%、29%和0%。IP组的生存率明显高于对照组（p<0.001）。除1例患者外，所有患者都能够居家。腹腔内化疗对无法切除的胃癌显示出局部和全身效应。
