Terashima M, Takagane A, Abe K, Kuboi M, Asahi H, Saito K
Dept. of Surgery 1, Iwate Medical University.
Gan To Kagaku Ryoho. 1994 Sep;21(13):2326-9.
In order to evaluate the biological response after intraperitoneal administration of OK-432 and CDDP, we studied the changes of cytokine levels in ascitic fluid. A total of 53 gastric cancer patients were included in this study. OK-432 20KE was administered in 7 patients and CDDP was administered in 4 patients intraperitoneally during operation. The IL-6, IL-8, TNF-alpha and sTNF RI levels in ascitic fluid were measured from 0 to 5 postoperative day. These results were compared with those obtained from the control groups (42 patients). The ascitic level of IL-6 increased immediately after operation, then gradually decreased. The elevations of IL-6 from 0 to 5 postoperative day were remarkably higher in the OK-432 treated group, and those on 0 and 1 postoperative days were remarkably lower in CDDP treated group than in the control group. Similarly, the ascitic level of IL-8 elevated soon after operation and then decreased gradually. In the OK-432 treated group, the ascitic level of IL-8 was significantly higher than in the control group from 0 to 2 postoperative day. Ascitic TNF-alpha was detectable only in the ascites soon after operation in the OK-432 treated group. The ascitic level of sTNF RI peaked on 2 postoperative day in the control and the OK-432 treated group and 1 postoperative day in the CDDP treated group. There were no significant differences between these groups.
为了评估腹腔内注射沙培林（OK-432）和顺铂（CDDP）后的生物学反应，我们研究了腹水细胞因子水平的变化。本研究共纳入53例胃癌患者。7例患者在手术期间腹腔内注射20KE沙培林，4例患者腹腔内注射顺铂。在术后0至5天测量腹水中白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、肿瘤坏死因子-α（TNF-α）和可溶性肿瘤坏死因子受体I（sTNF RI）水平。将这些结果与对照组（42例患者）的结果进行比较。术后IL-6腹水水平立即升高，然后逐渐下降。沙培林治疗组术后0至5天IL-6的升高明显高于对照组，顺铂治疗组术后0天和1天IL-6的升高明显低于对照组。同样，术后IL-8腹水水平很快升高，然后逐渐下降。在沙培林治疗组，术后0至2天IL-8腹水水平明显高于对照组。仅在沙培林治疗组术后不久的腹水中可检测到腹水TNF-α。对照组和沙培林治疗组sTNF RI腹水水平在术后第2天达到峰值，顺铂治疗组在术后第1天达到峰值。这些组之间无显著差异。
