Neda H, Watanabe N, Sone H, Yamauchi N, Niitsu Y, Urushizaki I
Gan To Kagaku Ryoho. 1986 Mar;13(3 Pt 1):593-7.
A 73-year-old female was diagnosed as having gastric cancer (undifferentiated adenocarcinoma), and received gastrojejunal anastomosis as an initial treatment. One year after the operation, she was readmitted to our hospital with the complaint of fullness in her stomach. Physical examination revealed a palpable mass in the epigastric region and ascites. An attempt to induce endogenous TNF was made using OK-432. Four doses of OK-432 (10 KE) were administered intraperitoneally every other day. Seven days after the last administration of OK-432 (10 KE), OK-432 (50 KE) was given at the same site to induce TNF. At 1.5h after the injection of OK-432 (50 KE), 20.8 U/ml and 8.1 U/ml of TNF activity could be detected respectively in the serum and ascites. This is the first report describing the induction of TNF in a cancer patient.
一名73岁女性被诊断为患有胃癌（未分化腺癌），并接受了胃空肠吻合术作为初始治疗。术后一年，她因胃部饱胀感再次入院。体格检查发现上腹部可触及肿块及腹水。尝试使用OK-432诱导内源性肿瘤坏死因子（TNF）。每隔一天腹腔注射四剂OK-432（10KE）。在最后一剂OK-432（10KE）给药七天后，在同一部位给予OK-432（50KE）以诱导TNF。在注射OK-432（50KE）后1.5小时，血清和腹水中分别可检测到20.8U/ml和8.1U/ml的TNF活性。这是描述在癌症患者中诱导TNF的首例报告。
