Kitamura M, Arai K, Iwasaki Y
Dept. of Surgery, Tokyo Metropolitan Komagome Hospital.
Gan To Kagaku Ryoho. 1994 Sep;21(13):2330-3.
Based on the experimental studies using Meth A and L 1210 transplantable mouse, which indicated that simultaneous combined administration of MMC and CDDP prolonged life span more significantly than individual administration, clinical application was performed on 14 cases with carcinomatous peritonitis in gastric cancer. One hundred mg of CDDP was administered before the closure of abdomen and drainage tubes were opened 2 hours later. Then, repeated administration of 10 mg/body of MMC and 40-50 mg/body of CDDP was continued once a month via the drug delivery system. Negative change of cytology was observed in seven out of 14 cases, and the prognosis of these patients was better than in the unchanged cytology group. Side effects such as severe gastro-intestinal symptoms and bone marrow toxicities were not recognized. Further studies should be done to confirm the efficacy of the intraperitoneal chemotherapy for carcinomatous peritonitis.
基于使用Meth A和L 1210可移植小鼠的实验研究，结果表明丝裂霉素C（MMC）和顺铂（CDDP）联合给药比单独给药更显著地延长了生存期，对14例胃癌癌性腹膜炎患者进行了临床应用。在关腹前给予100mg顺铂，2小时后开放引流管。然后，通过给药系统每月重复给予10mg/体的丝裂霉素C和40 - 50mg/体的顺铂。14例中有7例细胞学出现阴性变化，这些患者的预后优于细胞学未改变的组。未发现严重胃肠道症状和骨髓毒性等副作用。应进一步开展研究以证实腹腔内化疗对癌性腹膜炎的疗效。
