Hirao T, Imamoto H, Yamazaki K, Kan K, Takatsuka Y
Dept. of Surgery, Kansai Rosai Hospital.
Gan To Kagaku Ryoho. 1998 Jul;25(9):1442-4.
We examined the effects of intravenous infusion of 5-FU and intraperitoneal injection of low-dose CDDP on 3 cases with ascites owing to peritonitis carcinomatosa of postoperative gastric carcinoma and debility. Intravenous infusion of 5-FU (250-1,000 mg/body) and intraperitoneal injection of CDDP (20-25 mg/body) carried out for 2-5 days. As a result, QOL of 3 cases was fairly improved. The PS (Performance Status) of 2 cases improved from Grade 4 to 2, and another one improved from Grade 4 to 3. Adverse effects of Grade 1 according to the WHO criteria were observed in 1 case (leukocytopenia and diarrhea). This palliative chemotherapy method appeared to be safe and effective for ascites due to peritonitis carcinomatosa of postoperative gastric carcinoma and debility.
我们研究了静脉输注5-氟尿嘧啶（5-FU）和腹腔注射低剂量顺铂（CDDP）对3例因术后胃癌腹膜癌转移和身体虚弱而出现腹水的患者的影响。静脉输注5-FU（250-1000mg/人）和腹腔注射CDDP（20-25mg/人）持续2-5天。结果，3例患者的生活质量得到明显改善。2例患者的体力状况（PS）从4级改善到2级，另1例从4级改善到3级。根据世界卫生组织标准，1例患者出现1级不良反应（白细胞减少和腹泻）。这种姑息化疗方法对于术后胃癌腹膜癌转移和身体虚弱所致腹水似乎是安全有效的。
