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[Estimation of medroxyprogesterone acetate (MPA) and etoposide against a human uterine endometrial cancer].

作者信息

Ishizaki T, Yamamoto T, Itoh R, Yasuda J, Fujita H, Okada H

机构信息

Dept. of Obstetrics and Gynecology, Gamoucyo Hospital.

出版信息

Gan To Kagaku Ryoho. 1994 Oct;21(14):2521-3.

PMID:7944503
Abstract
摘要

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The hormone replacement therapy drug tibolone acts very similar to medroxyprogesterone acetate in an estrogen-and progesterone-responsive endometrial cancer cell line.在雌激素和孕激素反应性子宫内膜癌细胞系中，激素替代疗法药物替勃龙的作用与醋酸甲羟孕酮非常相似。
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Estrogen activates invasiveness of endometrial cancel cells to the interstitium.
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Vascular endothelial growth factor expression is not regulated by estradiol or medroxyprogesterone acetate in endometrial carcinoma.血管内皮生长因子的表达不受子宫内膜癌中雌二醇或醋酸甲羟孕酮的调控。
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Medroxyprogesterone acetate inhibits interleukin 6 secretion from KPL-4 human breast cancer cells both in vitro and in vivo: a possible mechanism of the anticachectic effect.醋酸甲羟孕酮在体内外均可抑制KPL-4人乳腺癌细胞分泌白细胞介素6：一种可能的抗恶病质作用机制。
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