高剂量丙戊酸所致的骨髓抑制
Bone marrow suppression induced by high dose valproic acid.
作者信息
Kishi T, Fujita N, Kawaguchi H, Ishimae M, Watanabe K, Tanaka T
机构信息
Department of Paediatrics, National Kure Hospital, Japan.
出版信息
Arch Dis Child. 1994 Aug;71(2):153-5. doi: 10.1136/adc.71.2.153.
Abstract
A girl with intractable epilepsy who received high dose valproic acid showed bone marrow suppression, which improved after the end of valproic acid treatment and the administration of supportive treatments. Valproic acid markedly suppressed the in vitro colony growth in this patient. It is believed that high dose valproic acid treatment directly suppressed the growth of haematopoietic progenitors, resulting in bone marrow failure.
摘要
一名接受高剂量丙戊酸治疗的难治性癫痫女孩出现了骨髓抑制，在丙戊酸治疗结束并给予支持性治疗后情况有所改善。丙戊酸显著抑制了该患者的体外集落生长。据信，高剂量丙戊酸治疗直接抑制了造血祖细胞的生长，导致骨髓衰竭。
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