Osca García J M, Beamud Gómez A, Ruíz Cerda J, Jabaloyas J M, Morera Martínez J, Jiménez Cruz J F
Servicio de Urología, Hospital La Fe, Valencia, España.
Arch Esp Urol. 1994 Jul-Aug;47(6):557-62.
From 1973 to 1991, 13 patients [4 females (30%) and 9 males (70%)] were diagnosed with adrenal carcinoma at our hospital. The mean age at the time of diagnosis was 47.4 years (range 29 to 72 yrs). Eleven patients (85%) presented with abdominal symptoms and 8 (61%) with paraneoplastic syndrome. At the time of diagnosis, 3 (23%) had clinical or radiological signs of metastasis. Five patients (38.5%) had regional involvement and 5 (38.5%) had localized disease. The preoperative imaging studies disclosed an abnormal IVP in 8 of 13 patients (61%); 7 of 10 (70%) had an abnormal ultrasound scan and the CT scan was abnormal in 9 out of 9 patients (100%). Seventy-three percent of the tumors were classified as anaplastic or poorly differentiated carcinoma and 27% as differentiated carcinoma. Complete surgical excision was performed in 8 cases and op'DDD was administered in 4 cases. The five-year survival rate was 30%. We can conclude that early diagnosis, staging and histopathology have a significant effect on survival and surgical excision is the only treatment associated with medium or long-term survival.
1973年至1991年期间，我院共诊断出13例肾上腺癌患者[4例女性（30%），9例男性（70%）]。诊断时的平均年龄为47.4岁（范围29至72岁）。11例患者（85%）出现腹部症状，8例（61%）出现副肿瘤综合征。诊断时，3例（23%）有临床或影像学转移征象。5例患者（38.5%）有区域受累，5例（38.5%）为局限性疾病。术前影像学检查显示，13例患者中有8例（61%）静脉肾盂造影异常；10例中有7例（70%）超声扫描异常，9例患者的CT扫描均异常（100%）。73%的肿瘤被分类为间变性或低分化癌，27%为高分化癌。8例患者接受了完整的手术切除，4例患者接受了双氯苯二氯乙烷治疗。五年生存率为30%。我们可以得出结论，早期诊断、分期和组织病理学对生存率有显著影响，手术切除是唯一与中长期生存相关的治疗方法。
