North J, Situnayake R D, Tikly M, Cremona A, Nicoll J, Kumararatne D S, Nuki G
Department of Rheumatology and Immunology, City Hospital NHS Trust, Birmingham, United Kingdom.
Ann Rheum Dis. 1994 Aug;53(8):543-6. doi: 10.1136/ard.53.8.543.
To assess the relationship between plasma levels of the cytokine interleukin-1 beta (IL-1 beta) and the progression of rheumatoid arthritis (RA).
Two subgroups of patients, one with persistently raised ESR (>/= 50 mm/hour, n = 16, group A) and one with persistently low ESR (</= 28 mm/hour), n = 18, group I) were chosen to represent stable extremes of inflammatory activity from a prospective study of 106 patients with active RA studied over one year in a single centre. The change from baseline in hand, foot and calcaneal bone mineral content measured by single photon absorptiometry and radiographic score of joint damage was measured over 12 months, together with plasma IL-1 beta and erythrocyte sedimentation rate.
Significant progression of joint damage occurred in both subgroups over one year (p < 0.0001, paired t test) though progression was significantly less in the subgroup with low ESR (p < 0.05, ANOVA). Hand and foot bone mineral content decreased by almost 10% in the subgroup with raised ESR (p < 0.005, paired t test). Stepwise linear regression analysis revealed significant independent relationships between radiographic progression over one year and plasma IL-1 beta and ESR (multiple R 0.674, F = 11.64, p < 0.0002). No such relationships were observed for changes in bone mineral content parameters.
Plasma IL-1 beta levels correlate weakly with progression of joint damage though not with loss of peripheral bone density in RA. A significant reduction in peripheral bone mineral content occurs over one year in patients with active RA with persistently raised ESR.
评估细胞因子白细胞介素-1β（IL-1β）的血浆水平与类风湿关节炎（RA）病情进展之间的关系。
从前瞻性研究的106例活动性RA患者中选取两个亚组，一组患者血沉持续升高（≥50毫米/小时，n = 16，A组），另一组患者血沉持续降低（≤28毫米/小时，n = 18，I组），以代表炎症活动稳定的两个极端情况。这些患者在单一中心进行了为期一年的研究。通过单光子吸收法测量手部、足部和跟骨的骨矿物质含量相对于基线的变化以及关节损伤的放射学评分，同时检测血浆IL-1β和红细胞沉降率，测量时间为12个月。
两个亚组在一年中均出现了关节损伤的显著进展（配对t检验，p < 0.0001），尽管血沉较低的亚组进展明显较少（方差分析，p < 0.05）。血沉升高的亚组中，手部和足部的骨矿物质含量下降了近10%（配对t检验，p < 0.005）。逐步线性回归分析显示，一年中的放射学进展与血浆IL-1β和血沉之间存在显著的独立关系（复相关系数R = 0.674，F = 11.64，p < 0.0002）。未观察到骨矿物质含量参数变化与上述因素之间存在此类关系。
在RA中，血浆IL-1β水平与关节损伤进展的相关性较弱，与外周骨密度丢失无关。血沉持续升高的活动性RA患者在一年中，外周骨矿物质含量显著降低。
