Eastgate J A, Symons J A, Wood N C, Grinlinton F M, di Giovine F S, Duff G W
University Department of Medicine, Northern General Hospital, Edinburgh.
Lancet. 1988 Sep 24;2(8613):706-9. doi: 10.1016/s0140-6736(88)90185-7.
The mean plasma level of interleukin 1 beta (IL-1 beta), measured by immunoassay, was significantly higher in 51 patients with rheumatoid arthritis (RA) than in 21 healthy controls of similar age. Further, in the RA group, plasma IL-1 beta correlated positively with Ritchie joint index, pain score, and erythrocyte sedimentation rate and correlated negatively with haemoglobin concentration. In individual patients with active disease who had serial measurements, plasma IL-1 beta also correlated with clinical disease activity. These results support the idea that IL-1 beta has a central role in the pathogenesis of RA.
通过免疫测定法测得，51例类风湿关节炎（RA）患者的白细胞介素1β（IL-1β）平均血浆水平显著高于21名年龄相仿的健康对照者。此外，在RA组中，血浆IL-1β与里奇关节指数、疼痛评分和红细胞沉降率呈正相关，与血红蛋白浓度呈负相关。在进行了系列测量的活动性疾病个体患者中，血浆IL-1β也与临床疾病活动相关。这些结果支持了IL-1β在RA发病机制中起核心作用这一观点。
