Ratsimamanga-Urverg S, Rasoanaivo P, Rafatro H, Robijaona B, Rakoto-Ratsimamanga A
Institut Malgache de Recherches Appliquées, Antananarivo, Madagascar.
Ann Trop Med Parasitol. 1994 Jun;88(3):271-7. doi: 10.1080/00034983.1994.11812867.
Three new isoquinoline alkaloid dimers with pavine and benzyl-tetrahydroisoquinoline moieties have been isolated, by bioassay-guided fractionation, from an alkaloid extract of Hernandia (= Hazomalania) voyronii Jumelle. All had inherent antiplasmodial activity in vitro and two enhanced chloroquine effectiveness in vitro in a dose-dependent manner. Some structure requirements for the chloroquine-potentiating action were identified in the isoquinoline series. These results, if confirmed in vivo, would account for the traditional use of H. voyronii as an adjuvant to complement chloroquine action in Malagasy herbal remedies.
通过生物活性导向分离法，从 Hernandia（= Hazomalania）voyronii Jumelle 的生物碱提取物中分离出了三种新的含有罂粟碱和苄基 - 四氢异喹啉部分的异喹啉生物碱二聚体。所有这些二聚体在体外均具有固有的抗疟活性，其中两种以剂量依赖方式增强了氯喹在体外的有效性。在异喹啉系列中确定了一些氯喹增效作用的结构要求。如果这些结果在体内得到证实，将解释马达加斯加草药中使用 Hernandia voyronii 作为辅助药物来补充氯喹作用的传统用法。
