Guinaudeau H, Böhlke M, Lin L Z, Angerhofer C K, Cordell G A
Program for Collaborative research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Iillinois, Chicago, 60612.
J Nat Prod. 1997 Mar;60(3):258-60. doi: 10.1021/np960568e.
Analysis of the alkaloidal fraction of the stem bark extract of Pachygone dasycarpa (Menispermaceae) resulted in the isolation of 10 known bisbenzylisoquinolines, (+)-tetrandrine, (+)-penduline, (+)-fangchinoline, (+)-atherospermoline, (+)-N-methyl-7-O-demethylpeinamine, (+)-daphnoline, (4-)-isotrilobine (1), (+)-cocsuline (2), (+)-tricordatine (3), (+)-2'-norcocsuline, and the new alkaloid (+)-12-O-methyltricordatine (4). The last bisbenzylisoquinoline alkaloid isolated, (+)-angchibangkine (5), is the first member of this alkaloid class found to possess three diphenyl ether bridges in the 7-6',8-7', and 11-12' positions. Structure elucidation of these alkaloids and of (+)-O-methylangchibangkine (6) was achieved by analysis of spectral data. Compounds 4-6 show antiplasmodial activity against Plasmodium falciparum.
对厚果崖爬藤（防己科）茎皮提取物的生物碱部分进行分析，从中分离出10种已知的双苄基异喹啉生物碱：（+）-汉防己甲素、（+）-悬垂千金藤碱、（+）-粉防己碱、（+）-南五味子碱、（+）-N-甲基-7-O-去甲基青藤碱、（+）-蝙蝠葛诺林碱、（-）-异三叶木防己碱（1）、（+）-考库苏林碱（2）、（+）-三心皮碱（3）、（+）-2'-去甲考库苏林碱，以及新生物碱（+）-12-O-甲基三心皮碱（4）。最后分离得到的双苄基异喹啉生物碱（+）-安奇班金碱（5）是该生物碱类中首个被发现于7-6'、8-7'和11-12'位具有三个二苯醚桥的成员。通过光谱数据分析确定了这些生物碱以及（+）-O-甲基安奇班金碱（6）的结构。化合物4-6对恶性疟原虫显示出抗疟活性。
