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严重钙化不影响二尖瓣修复的长期效果。

Severe calcification does not affect long-term outcome of mitral valve repair.

作者信息

Grossi E A, Galloway A C, Steinberg B M, LeBoutillier M, Delianides J, Baumann F G, Spencer F C, Colvin S B

机构信息

Department of Surgery, New York University Medical Center, New York 10016.

出版信息

Ann Thorac Surg. 1994 Sep;58(3):685-7; discussion 688. doi: 10.1016/0003-4975(94)90728-5.

Abstract

Some surgeons have suggested that the presence of severe calcification in the mitral valve annulus or leaflets precludes successful repair. Our institution has attempted to repair these calcified valves when good annular and leaflet mobility could be achieved by annular debridement and leaflet resection. From June 1979 through June 1993 558 mitral valve repairs were performed using Carpentier's techniques. When calcified valves were encountered, these techniques were modified to include annular debridement and mechanical leaflet decalcification. Calcification was identified preoperatively in 49 patients (8.8%) by either left ventricular fluoroscopy or echocardiography and was debrided in 64 patients (11.5%). This included 24 annular debridements, 28 leaflet debridements, and 12 annular and leaflet debridements. Patient ages ranged from 13 to 83 years (mean age, 62.3 years), and 25 patients (39.1%, 25/64) had concomitant cardiac procedures. Operative mortality was 6.2% (4/64) overall and 2.6% (1/39) for isolated mitral valve repairs. Calcium debridement was performed in 19.3% (23/119) of patients with a rheumatic cause compared with 9.3% (41/439) of the nonrheumatic patients (p < 0.01). Long-term follow-up revealed the necessity for reoperation in 7.8% (5/64) in patients with calcium debridement as compared with 7.7% (38/494) with no debridement (p = not significant). Cumulative freedom from reoperation at 10 years was 83.3% for all patients, 88.1% for debrided patients, and 82.6% for nondebrided patients (p = not significant). Cox proportional hazards analysis revealed that the presence of rheumatic disease significantly increased the risk of reoperation (odds ratio = 3.28; p < 0.001), whereas calcium debridement had no significant effect. These results demonstrate that when good annulus and leaflet motion can be achieved in calcified mitral valves, calcium debridement allows durable repairs.

摘要

一些外科医生认为,二尖瓣环或瓣叶存在严重钙化会妨碍成功修复。当通过环行清创术和瓣叶切除术能够实现良好的瓣环和瓣叶活动度时,我们机构尝试对这些钙化瓣膜进行修复。从1979年6月至1993年6月,采用卡彭蒂埃技术进行了558例二尖瓣修复术。当遇到钙化瓣膜时,这些技术会进行改良,包括环行清创术和机械性瓣叶脱钙。术前通过左心室荧光透视或超声心动图在49例患者(8.8%)中发现钙化,并在64例患者(11.5%)中进行了清创。这包括24例环行清创、28例瓣叶清创以及12例环行和瓣叶清创。患者年龄范围为13至83岁(平均年龄62.3岁),25例患者(39.1%,25/64)同时进行了心脏手术。总体手术死亡率为6.2%(4/64),单纯二尖瓣修复术的手术死亡率为2.6%(1/39)。风湿性病因患者中19.3%(23/119)进行了钙清创,而非风湿性患者中这一比例为9.3%(41/439)(p<0.01)。长期随访显示,进行钙清创的患者中有7.8%(5/64)需要再次手术,未进行清创的患者中这一比例为7.7%(38/494)(p=无显著差异)。所有患者10年时再次手术的累积自由度为83.3%,清创患者为88.1%,未清创患者为82.6%(p=无显著差异)。Cox比例风险分析显示,风湿性疾病的存在显著增加了再次手术的风险(比值比=3.28;p<0.001),而钙清创没有显著影响。这些结果表明,当钙化二尖瓣能够实现良好的瓣环和瓣叶活动度时,钙清创可实现持久修复。

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