Plomin R, Pedersen N L, Lichtenstein P, McClearn G E
Center for Developmental and Health Genetics, Pennsylvania State University, University Park 16802.
Behav Genet. 1994 May;24(3):207-15. doi: 10.1007/BF01067188.
The powerful quantitative genetic design of identical and fraternal twins reared apart (112 pairs) and matched twins reared together (111 pairs) was employed to assess the extent of genetic influence on individual differences in cognitive abilities during the last half of the life span. General cognitive ability yielded a heritability estimate of about .80 in two assessments 3 years apart as part of the Swedish Adoption/Twin Study of Aging. This is one of the highest heritabilities reported for a behavioral trait. Across the two ages, average heritabilities are about .60 for verbal tests, .50 for spatial and speed-of-processing tests, and .40 for memory tests. For general cognitive ability, the phenotypic stability across the 3 years is .92 and stable genetic factors account for nearly 90% this stability. These findings suggest that general cognitive ability is a reasonable target for research that aims to identify specific genes for complex traits.
本研究采用了强大的定量遗传设计,涉及分开抚养的同卵和异卵双胞胎(112对)以及一起抚养的匹配双胞胎(111对),以评估在生命后期遗传因素对认知能力个体差异的影响程度。作为瑞典老年收养/双胞胎研究的一部分,相隔3年的两次评估中,一般认知能力的遗传率估计约为0.80。这是已报道的行为特征中最高的遗传率之一。在这两个年龄段,语言测试的平均遗传率约为0.60,空间和处理速度测试为0.50,记忆测试为0.40。对于一般认知能力,3年间的表型稳定性为0.92,稳定的遗传因素占这种稳定性的近90%。这些发现表明,一般认知能力是旨在识别复杂性状特定基因的研究的合理目标。