Duvekot J J, Cheriex E C, Tan W D, Heidendal G A, Peeters L L
Department of Obstetrics and Gynecology, University Hospital Maastricht, The Netherlands.
Basic Res Cardiol. 1994 May-Jun;89(3):270-7. doi: 10.1007/BF00795619.
To assess the hypothesis that echocardiographic variables vary as a function of baseline blood volume and change in response to changes in vascular filling state, we evaluated the relationship between the atrial and ventricular dimensions and left ventricular function, as measured by combined Doppler and M-mode echocardiography on the one hand, and blood volume as measured by a standard radioactive isotope technique on the other. Furthermore, we determined the effect of an increment in vascular filling state induced by plasma volume expansion. Test subjects were ten male and six female volunteers. Blood volume/kg was the only factor not different between male and female subjects and therefore suitable for our study. None of the echocardiographic variables correlated with blood volume/kg. Volume loading increased stroke volume, left atrial diameter, right atrial area, left ventricular end-diastolic dimension, mean velocity of circumferential fiber shortening and left ventricular ejection time. It is concluded that echocardiographic variables are unsuitable for estimating blood volume. Serial measurements of atrial dimensions and left ventricular dimensions are useful for detecting rapid changes in vascular filling state.
为了评估超声心动图变量随基线血容量变化以及对血管充盈状态变化做出反应而改变这一假设，我们一方面通过联合多普勒和M型超声心动图测量心房和心室尺寸以及左心室功能之间的关系，另一方面通过标准放射性同位素技术测量血容量。此外，我们还确定了血浆容量扩张引起的血管充盈状态增加的影响。测试对象为10名男性和6名女性志愿者。每千克体重的血容量是男性和女性受试者之间唯一无差异的因素，因此适合我们的研究。没有任何超声心动图变量与每千克体重的血容量相关。容量负荷增加了每搏输出量、左心房直径、右心房面积、左心室舒张末期尺寸、圆周纤维缩短平均速度和左心室射血时间。结论是超声心动图变量不适合估计血容量。对心房尺寸和左心室尺寸进行连续测量有助于检测血管充盈状态的快速变化。
