Duvekot J J, Cheriex E C, Tan W D, Heidendal G A, Peeters L L
Academic Hospital Maastricht, The Netherlands.
Cardiovasc Res. 1994 Aug;28(8):1269-72. doi: 10.1093/cvr/28.8.1269.
The aim was to determine whether measurement of the anterior-posterior diameter of the inferior vena cava (IVC) by ultrasonography, before and during deep inspiration, allows indirect information on baseline blood volume and changes in vascular filling state to be obtained in healthy subjects.
Blood volume was measured in 12 volunteers by a standard radioactive isotope method. The IVC dimensions were measured by ultrasound in various positions. In addition, in 10 male subjects the effect on the IVC dimensions of volume loading was evaluated by rapid infusion of plasma expander. During and immediately following volume loading, the IVC dimensions and blood volume were remeasured.
Neither the baseline IVC diameters nor any combination of these variables correlated with the concomitant blood volume. Volume loading increased the anterior-posterior IVC dimensions linearly, the largest increase being observed with the maximum IVC diameter and the subject in supine position.
It follows that ultrasonic IVC indices cannot be used as accurate indirect estimate of baseline blood volume, but provide reliable information on acute changes of the subjects' vascular filling state.
本研究旨在确定通过超声测量深吸气前后下腔静脉（IVC）的前后径，能否获取健康受试者的基线血容量及血管充盈状态变化的间接信息。
采用标准放射性同位素法测量12名志愿者的血容量。通过超声在不同位置测量IVC尺寸。此外，对10名男性受试者快速输注血浆扩容剂，评估容量负荷对IVC尺寸的影响。在容量负荷期间及之后立即重新测量IVC尺寸和血容量。
基线IVC直径及这些变量的任何组合均与同期血容量无相关性。容量负荷使IVC前后径呈线性增加，最大IVC直径及受试者仰卧位时增加最为明显。
由此可见，超声IVC指标不能作为基线血容量的准确间接估计，但可提供有关受试者血管充盈状态急性变化的可靠信息。
