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1
Human seminal plasma contains somatostatin-64.人类精浆中含有生长抑素-64。
Biochem J. 1994 Oct 1;303 ( Pt 1)(Pt 1):263-8. doi: 10.1042/bj3030263.
2
Canine prosomatostatin: isolation of a cDNA, regulation of gene expression, and characterization of post-translational processing intermediates.犬生长抑素原：cDNA的分离、基因表达调控及翻译后加工中间体的特性分析
Regul Pept. 1996 Dec 17;67(3):145-52. doi: 10.1016/s0167-0115(96)00126-7.
3
Somatostatin-28 [1-12]-like peptides.生长抑素-28 [1-12]样肽
Adv Exp Med Biol. 1985;188:89-107. doi: 10.1007/978-1-4615-7886-4_6.
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Prosomatostatin-I is processed to somatostatin-26 and somatostatin-14 in the pancreas of the bowfin, Amia calva.前生长抑素-I在弓鳍鱼（Amia calva）的胰腺中被加工成生长抑素-26和生长抑素-14。
Regul Pept. 1993 Aug 13;47(1):33-9. doi: 10.1016/0167-0115(93)90270-i.
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Primary structures of somatostatins from the islet organ of the hagfish suggest an anomalous pathway of posttranslational processing of prosomatostatin-1.
Endocrinology. 1988 May;122(5):1855-9. doi: 10.1210/endo-122-5-1855.
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Processing of an anglerfish somatostatin precursor to a hydroxylysine-containing somatostatin 28.将鮟鱇鱼生长抑素前体加工成含羟赖氨酸的生长抑素28 。
Proc Natl Acad Sci U S A. 1985 Jan;82(2):277-81. doi: 10.1073/pnas.82.2.277.
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Peptides derived by processing of rat prosomatostatin near the amino-terminus: characterization, tissue distribution, and release.大鼠前生长抑素在氨基末端附近加工产生的肽：特性、组织分布及释放
Endocrinology. 1990 Apr;126(4):2054-61. doi: 10.1210/endo-126-4-2054.
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Fragments of prosomatostatin isolated from a human pancreatic tumour.从人胰腺肿瘤中分离出的前生长抑素片段。
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Post-translational processing of anglerfish islet somatostatin precursors.琵琶鱼胰岛生长抑素前体的翻译后加工
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Prosomatostatin 1-64 is a major product of somatostatin gene expression in pancreas and gut.前生长抑素1-64是生长抑素基因在胰腺和肠道中表达的主要产物。
J Biol Chem. 1989 Jun 25;264(18):10633-6.

引用本文的文献

1
Effects of spinal cord injury on semen parameters.脊髓损伤对精液参数的影响。
J Spinal Cord Med. 2008;31(1):27-32. doi: 10.1080/10790268.2008.11753977.

本文引用的文献

1
Human prostatic gastricsinogen: the precursor of seminal fluid acid proteinase.人前列腺胃蛋白酶原：精液酸性蛋白酶的前体。
Arch Biochem Biophys. 1981 Aug;210(1):14-20. doi: 10.1016/0003-9861(81)90158-2.
2
Somatostatin and/or somatostatin-like immunoreactive endocrine-paracrine cells in the human prostate gland.
Arch Pathol Lab Med. 1984 Sep;108(9):693-6.
3
Rat pre-prosomatostatin. Structure and processing by microsomal membranes.大鼠前促生长抑素原。结构及微粒体膜的加工过程。
J Biol Chem. 1983 May 10;258(9):5570-3.
4
On the accuracy of radioimmunological determination of somatostatin in plasma.关于血浆中生长抑素放射免疫测定的准确性
Regul Pept. 1982 Jun;4(1):13-31. doi: 10.1016/0167-0115(82)90105-7.
5
Human somatostatin I: sequence of the cDNA.人生长抑素I：cDNA序列
Proc Natl Acad Sci U S A. 1982 Aug;79(15):4575-9. doi: 10.1073/pnas.79.15.4575.
6
Heterogeneity of somatostatin like immunoreactivity (SLI) in extracts of porcine, canine and human pancreas.猪、犬和人胰腺提取物中生长抑素样免疫反应性（SLI）的异质性。
Acta Endocrinol (Copenh). 1981 Dec;98(4):564-72. doi: 10.1530/acta.0.0980564.
7
Isolation and structure of pro-somatostatin: a putative somatostatin precursor from pig hypothalamus.猪下丘脑促生长抑素原的分离与结构：一种假定的生长抑素前体
Proc Natl Acad Sci U S A. 1980 Aug;77(8):4489-93. doi: 10.1073/pnas.77.8.4489.
8
The chymotrypsin-like activity of human prostate-specific antigen, gamma-seminoprotein.人前列腺特异性抗原γ-精浆蛋白的类胰凝乳蛋白酶活性
FEBS Lett. 1987 Dec 10;225(1-2):168-72. doi: 10.1016/0014-5793(87)81151-1.
9
Somatostatin receptors on rat cerebrocortical membranes. Structural characterization of somatostatin-14 and somatostatin-28 receptors and comparison with pancreatic type receptors.
J Biol Chem. 1988 Oct 5;263(28):14441-5.
10
Characterization of three peptides derived from prosomatostatin [prosomatostatin-(1-63)-, -(65-76)- and -(79-92)-peptides] in a human pancreatic tumour.人胰腺肿瘤中源自前生长抑素的三种肽[前生长抑素-(1 - 63)-、-(65 - 76)-和-(79 - 92)-肽]的特性分析
Biochem J. 1987 Nov 15;248(1):123-7. doi: 10.1042/bj2480123.

人类精浆中含有生长抑素-64。

Human seminal plasma contains somatostatin-64.

作者信息

Odum L, Johnsen A H

机构信息

Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Denmark.

出版信息

Biochem J. 1994 Oct 1;303 ( Pt 1)(Pt 1):263-8. doi: 10.1042/bj3030263.

DOI:10.1042/bj3030263
PMID:7945250
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1137585/
Abstract

Prosomatostatin is processed into two biologically active peptides, somatostatin (SS)-14 and SS-28. SS-14 is found in many tissues, whereas SS-28 is most prominent in the intestine. Human seminal plasma contained high concentrations (median = 3 nmol/l, range 0.6-76 nmol/l, n = 17) of SS with a higher M(r) than that of SS-28 as determined by gel chromatography. After isolation the SS immunoreactivity was identified as SS-64 based on the N-terminal amino acid sequence Leu-Ala-Glu-Leu-Leu-Ser-Glu-Pro-Asn-Gln-, and M(r) of 7242 determined by m.s. and on reactivity with two antibodies raised against SS-14. SS-64 displaced the binding of [125I-Tyr1]SS-14 to rat cerebrocortical membranes as effectively as SS-14 (IC50 = 1.6 mol/l). The concentration of SS-64 in seminal plasma from vasectomized men was significant higher (P < 0.005) than in normal men (median = 25.4 nmol/l, range 1.5-156 nmol/l, n = 21), suggesting that the synthesis of SS-64 takes place in the male accessory sex glands.

摘要

前生长抑素被加工成两种具有生物活性的肽，即生长抑素（SS）-14和SS-28。SS-14在许多组织中都有发现，而SS-28在肠道中最为显著。通过凝胶色谱法测定，人类精液中含有高浓度（中位数 = 3 nmol/l，范围0.6 - 76 nmol/l，n = 17）的SS，其相对分子质量高于SS-28。分离后，根据N端氨基酸序列Leu-Ala-Glu-Leu-Leu-Ser-Glu-Pro-Asn-Gln-以及质谱测定的相对分子质量7242，并结合与两种针对SS-14产生的抗体的反应性，将SS免疫反应性鉴定为SS-64。SS-64与[125I-Tyr1]SS-14竞争结合大鼠脑皮质膜的能力与SS-14相当（IC50 = 1.6 mol/l）。输精管切除男性精液中SS-64的浓度显著高于正常男性（P < 0.005）（中位数 = 25.4 nmol/l，范围1.5 - 156 nmol/l，n = 21），这表明SS-64是在男性附属性腺中合成的。