大鼠淋巴细胞中血管活性肠肽受体的基因表达。
Gene expression of VIP receptor in rat lymphocytes.
作者信息
Gomariz R P, Garrido E, Leceta J, Martinez C, Abalo R, Delgado M
机构信息
Departamento Biologia Celular, Facultad de Biologia, Universidad Complutense, Madrid, Spain.
出版信息
Biochem Biophys Res Commun. 1994 Sep 30;203(3):1599-604. doi: 10.1006/bbrc.1994.2369.
In the present report we analyze by reverse transcription (RT) and polymerase chain reaction (PCR) the expression of vasoactive intestinal peptide receptors (VIP-R) in rat thymocytes and peripheral T and B lymphocytes. We have obtained a specific VIP-R cDNA product of 311 bp identical in size to that obtained from lung. These results have been confirmed by Southern hybridization analysis. VIP receptor gene expression in central and peripheral lymphoid organs support the notion that VIP is a immunomodulatory peptide.
在本报告中，我们通过逆转录（RT）和聚合酶链反应（PCR）分析了大鼠胸腺细胞以及外周T和B淋巴细胞中血管活性肠肽受体（VIP-R）的表达。我们获得了一个311 bp的特异性VIP-R cDNA产物，其大小与从肺中获得的产物相同。这些结果已通过Southern杂交分析得到证实。VIP受体基因在中枢和外周淋巴器官中的表达支持了VIP是一种免疫调节肽的观点。
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