Essardas Daryanani H, Santolaria F J, Gonzalez Reimers E, Jorge J A, Batista Lopez N, Martin Hernandez F, Martinez Riera A, Rodriguez Rodriguez E
Department of Internal Medicine, University Hospital of Canarias, La Laguna, Tenerife, Canary Islands, Spain.
Alcohol Alcohol. 1994 May;29(3):323-8.
A study of 72 alcoholics, hospitalized for alcohol withdrawal syndrome, was undertaken to determine the incidence of seizures, their relationship with other withdrawal symptoms, the presence of brain atrophy and the relationship of this last with withdrawal intensity severity. Sixty-seven (93%) were male and the mean age was 44.9 +/- 1.3 (mean +/- SEM) years. Thirty-three (46%) of the 72 patients had seizures at admission, 10 of these developed minor withdrawal symptoms, in 18 delirium tremens ensued and 5 showed no symptoms of withdrawal. Thirty-nine (54%) had withdrawal syndrome without seizures. Twenty-one of these developed minor withdrawal syndrome and 18 delirium tremens. Seizures showed no relationship with the other withdrawal manifestations, and in all the cases preceded them. Our findings also show that alcoholics with seizures due to withdrawal are more prone to suffer seizures in their future withdrawal episodes, and that alcoholics who suffer morning withdrawal symptoms are prone to develop delirium tremens. In 46 patients a CT scan was performed. Though the alcoholics showed ventricular and sulcal enlargement, brain atrophy was similar when the seizure and non-seizure groups or those with and without delirium tremens were compared. However, cortical and ventricular atrophy were related to the existence of previous episodes of withdrawal syndrome [corrected].
对72名因酒精戒断综合征住院的酗酒者进行了一项研究，以确定癫痫发作的发生率、其与其他戒断症状的关系、脑萎缩的存在情况以及脑萎缩与戒断强度严重程度的关系。67名（93%）为男性，平均年龄为44.9±1.3（均值±标准误）岁。72名患者中有33名（46%）在入院时出现癫痫发作，其中10名出现轻微戒断症状，18名随后发生震颤谵妄，5名未出现戒断症状。39名（54%）有戒断综合征但无癫痫发作。其中21名出现轻微戒断综合征，18名发生震颤谵妄。癫痫发作与其他戒断表现无关，且在所有病例中均先于其他戒断表现出现。我们的研究结果还表明，因戒断而出现癫痫发作的酗酒者在未来的戒断发作中更容易发生癫痫发作，且出现早晨戒断症状的酗酒者更容易发展为震颤谵妄。对46名患者进行了CT扫描。尽管酗酒者显示脑室和脑沟扩大，但在比较癫痫发作组和非癫痫发作组或有和无震颤谵妄的患者时，脑萎缩情况相似。然而，皮质和脑室萎缩与既往戒断综合征发作的存在有关[校正后]。
