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宫内暴露于苯妥英钠导致的基底凹陷和中线骨骼异常。

Basilar invagination and mid-line skeletal abnormalities due to in utero exposure to phenytoin.

作者信息

Marks P, Mills B, West L

机构信息

Department of Neurosurgery, Auckland Hospital, New Zealand.

出版信息

Br J Neurosurg. 1994;8(3):365-8. doi: 10.3109/02688699409029628.

DOI:10.3109/02688699409029628
PMID:7946029
Abstract

A case of basilar invagination which is thought to have arisen from the patient's intrauterine exposure to phenytoin is presented. The patient was treated surgically by foramen magnum decompression and occipito-cervical fusion, and by transoral resection of the clivus. His symptoms of brain stem compression were alleviated and the role of phenytoin in the production of his craniocervical abnormality is discussed.

摘要

本文报告一例被认为因患者子宫内接触苯妥英钠而引发的基底凹陷症。该患者接受了枕骨大孔减压和枕颈融合手术以及经口斜坡切除术。其脑干受压症状得到缓解,并对苯妥英钠在其颅颈异常发生过程中的作用进行了讨论。

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