Galán J E
Department of Molecular Genetics and Microbiology, School of Medicine, State University of New York at Stony Brook 11794-5222.
Curr Opin Immunol. 1994 Aug;6(4):590-5. doi: 10.1016/0952-7915(94)90146-5.
It is becoming increasingly clear that bacterial pathogens can manipulate the host cell to their advantage. Recently, we have learnt more about the different strategies that microorganisms have evolved to subvert normal host-cellular functions. These strategies allow bacteria to gain access to, survive, and replicate within host cells, as well as to spread to neighboring cells, without the need for an extracellular phase. During the next few years, we expect to learn much more about these mechanisms and, in the process, it is likely that we will learn more about the host itself.
越来越明显的是，细菌病原体能够以对自身有利的方式操纵宿主细胞。最近，我们对微生物进化出的不同策略有了更多了解，这些策略可颠覆正常的宿主细胞功能。这些策略使细菌能够进入宿主细胞、在其中存活和复制，还能扩散到邻近细胞，而无需经历细胞外阶段。在未来几年里，我们期望对这些机制有更多了解，在此过程中，我们很可能也会对宿主本身有更多认识。
