Pamer E G
Yale University, New Haven.
Curr Opin Immunol. 1993 Aug;5(4):492-6. doi: 10.1016/0952-7915(93)90028-q.
Great progress has been made in understanding the mechanisms bacteria use to invade, survive and move within eukaryotic cells. It is clear that bacteria have found ways to manipulate host cell signal transduction pathways and the cytoskeleton to their advantage. To defend against prokaryotic invaders, the immune system has evolved mechanisms for the specific recognition of bacterial antigens.
在理解细菌侵入真核细胞、在其中存活和移动所使用的机制方面已经取得了巨大进展。很明显，细菌已经找到了利用宿主细胞信号转导途径和细胞骨架来为自身谋利的方法。为了抵御原核入侵者，免疫系统已经进化出了特异性识别细菌抗原的机制。
