Ahlgren J, Stål O, Westman G, Arnesson L G
Dept of Oncology, Medical Centre Hospital, Orebro, Sweden.
Acta Oncol. 1994;33(6):603-8. doi: 10.3109/02841869409121769.
To define a subgroup of patients, in whom axillary dissection could be omitted, we analysed the frequency of pathologically confirmed lymph node metastases depending on tumour size, hormonal receptors, DNA ploidy, S-phase fraction (SPF), and clinical nodal status among 1,145 patients with stage I-II breast cancer from an area with ongoing screening. Clinical nodal status and tumour size were strongly correlated to pathological nodal status. Also SPF > 10% was strongly correlated to node positivity in univariate analysis. In multivariate analysis there was still a significant correlation among cases with tumour size < or = 20 mm. In conclusion, patients with clinically negative nodal status, and tumour size < or = 20 mm and < or = 10 mm had pathologically positive nodes in 25% and 15% of cases respectively. The addition of SPF did not lower these figures significantly since small tumours with high SPF are few.
为了确定可以省略腋窝清扫术的患者亚组，我们分析了1145例来自正在进行筛查地区的I-II期乳腺癌患者中，根据肿瘤大小、激素受体、DNA倍体、S期细胞分数（SPF）和临床淋巴结状态，病理确诊的淋巴结转移频率。临床淋巴结状态和肿瘤大小与病理淋巴结状态密切相关。在单因素分析中，SPF>10%也与淋巴结阳性密切相关。在多因素分析中，肿瘤大小≤20mm的病例之间仍存在显著相关性。总之，临床淋巴结状态为阴性、肿瘤大小≤20mm和≤10mm的患者，病理阳性淋巴结的比例分别为25%和15%。由于高SPF的小肿瘤很少，增加SPF并没有显著降低这些数字。
