Murakami R, Yoshimatsu S, Yamashita Y, Sagara K, Arakawa A, Takahashi M
Department of Radiology, Kumamoto University School of Medicine, Japan.
Acta Radiol. 1994 Nov;35(6):576-80.
Lipiodol accumulation patterns were correlated with local recurrences after subsegmental or conventional arterial chemoembolization therapy using iodized oil (Lipiodol-TAE). Thirty-six patients with solitary small hepatocellular carcinomas (HCCs) less than 3 cm in diameter were included in this retrospective study. Superselective subsegmental catheterization was performed in 14 patients (subsegmental Lipiodol-TAE). In the remaining 22 cases, embolization was performed from the proximal portion of the hepatic artery (conventional Lipiodol-TAE). Patterns of Lipiodol accumulations within the tumors were classified in 2 groups: complete and incomplete accumulation. Complete accumulation was observed in 71% of subsegmental Lipiodol-TAE and in 32% of conventional Lipiodol-TAE. The rate of local recurrences within 12 months was significantly higher (p < 0.01) in incomplete accumulation (100%) than in complete accumulation (13%). We suggest that when small HCCs are to be treated with TAE, subsegmental Lipiodol-TAE should be performed because of its superior capability for achieving complete Lipiodol accumulation.
碘油聚集模式与使用碘化油（碘油肝动脉化疗栓塞术）进行亚段或传统动脉化疗栓塞治疗后的局部复发相关。本回顾性研究纳入了36例直径小于3 cm的孤立性小肝细胞癌（HCC）患者。14例患者进行了超选择性亚段导管插入术（亚段碘油肝动脉化疗栓塞术）。其余22例中，从肝动脉近端进行栓塞（传统碘油肝动脉化疗栓塞术）。肿瘤内碘油聚集模式分为两组：完全聚集和不完全聚集。在亚段碘油肝动脉化疗栓塞术患者中，71%观察到完全聚集，在传统碘油肝动脉化疗栓塞术患者中为32%。不完全聚集组（100%）12个月内局部复发率显著高于完全聚集组（13%）（p < 0.01）。我们建议，当小HCC采用肝动脉化疗栓塞术治疗时，应进行亚段碘油肝动脉化疗栓塞术，因为其实现碘油完全聚集的能力更强。
