Matsuo N, Uchida H, Nishimine K, Soda S, Oshima M, Nakano H, Nagano N, Nishimura Y, Yoshioka T, Guo Q
Department of Radiology, Nara Medical University, Japan.
J Vasc Interv Radiol. 1993 Jul-Aug;4(4):543-9. doi: 10.1016/s1051-0443(93)71918-1.
Segmental transcatheter arterial embolization (TAE) with use of iodized oil mixed with an anticancer drug, followed by injection of gelatin sponge particles, was undertaken to evaluate its antitumor effect and its influence on normal tissue in patients with hepatocellular carcinoma (HCC).
Histologic findings in 12 patients who underwent hepatectomy after segmental TAE were compared with findings on plain radiographs and computed tomographic (CT) scans. Visualization of the portal veins contiguous to the tumor on radiographs and the pattern of iodized oil accumulation in the tumor and vicinity on CT scans after TAE were assessed.
Complete necrosis of the tumor was achieved in 10 cases (83%), while complete necrosis of daughter nodules and capsular invasion was observed histologically in eight of these 10 patients (80%). The degree of tumor necrosis correlated with the pattern of iodized oil accumulation in and near the tumor. Partial necrosis of normal tissue near the tumor correlated with accumulation of iodized oil.
Segmental TAE may be an excellent therapeutic method for treatment of HCC that is localized in one or a few segmental or subsegmental regions.
采用碘化油与抗癌药物混合进行节段性经导管动脉栓塞术（TAE），随后注射明胶海绵颗粒，以评估其对肝细胞癌（HCC）患者的抗肿瘤效果及其对正常组织的影响。
将12例行节段性TAE后接受肝切除术的患者的组织学检查结果与X线平片和计算机断层扫描（CT）结果进行比较。评估TAE后X线片上与肿瘤相邻的门静脉的显影情况以及CT扫描上肿瘤及其附近碘化油的聚集模式。
10例（83%）实现了肿瘤完全坏死，其中8例（80%）在组织学上观察到子结节完全坏死和包膜侵犯。肿瘤坏死程度与肿瘤内及肿瘤附近碘化油的聚集模式相关。肿瘤附近正常组织的部分坏死与碘化油的聚集有关。
节段性TAE可能是治疗局限于一个或几个节段或亚节段区域的HCC的一种极佳治疗方法。
