Petersen-Felix S, Arendt-Nielsen L, Bak P, Bjerring P, Breivik H, Svensson P, Zbinden A M
Department of Anaesthesiology and Intensive Care, University Hospital of Berne, Switzerland.
Br J Anaesth. 1994 Sep;73(3):326-30. doi: 10.1093/bja/73.3.326.
5-Hydroxytryptamine (5-HT) causes antinociception via presynaptic 5-HT3 (5-HT subtype 3) receptors on primary afferent nociceptive neurones in the spinal cord dorsal horn. Therefore, ondansetron (a 5-HT3 receptor antagonist) may increase the perception of a noxious stimulus or decrease the effects of concurrently administered antinociceptive drugs. Using a randomized, double-blind, crossover study design, we have tested this hypothesis in eight healthy volunteers who, on three different days, received either ondansetron and placebo, ondansetron and alfentanil or placebo and alfentanil. Experimental pain was induced with heat, cold, mechanical pressure and electrical stimulation. Ondansetron alone did not change the response to any of the experimental tests, but alfentanil and the combination ondansetron-alfentanil significantly changed the response compared with ondansetron alone. There was no difference between alfentanil alone and the combination ondansetron-alfentanil. We conclude that ondansetron does not change the response to pressure, heat, cold or electrical nociceptive stimuli or antagonize the analgesic effect of alfentanil.
5-羟色胺（5-HT）通过脊髓背角初级传入伤害性神经元上的突触前5-HT3（5-HT3型）受体发挥抗伤害感受作用。因此，昂丹司琼（一种5-HT3受体拮抗剂）可能会增强对有害刺激的感知，或降低同时给予的抗伤害感受药物的效果。我们采用随机、双盲、交叉研究设计，在8名健康志愿者身上检验了这一假设，这些志愿者在三个不同的日子里分别接受了昂丹司琼和安慰剂、昂丹司琼和阿芬太尼或安慰剂和阿芬太尼。通过热、冷、机械压力和电刺激诱导实验性疼痛。单独使用昂丹司琼并未改变对任何实验测试的反应，但与单独使用昂丹司琼相比，阿芬太尼以及昂丹司琼与阿芬太尼联用显著改变了反应。单独使用阿芬太尼与昂丹司琼 - 阿芬太尼联用之间没有差异。我们得出结论，昂丹司琼不会改变对压力、热、冷或电伤害性刺激的反应，也不会拮抗阿芬太尼的镇痛作用。
