Frappaz D, Bouffet E, Thiesse P, Mottolese C, Artiges V, Grabois M, Combaret V, Desuzinges C, Favrot M, Brunat Mentigny M
Pediatric Unit, Centre L. Bérard, Lyon, France.
Pediatr Hematol Oncol. 1994 Jul-Aug;11(4):439-43. doi: 10.3109/08880019409140545.
Neuroblastoma may present with spinal cord compression due to dumbbell extension of thoracic or abdominal disease. Isolated intraspinal involvement as the sole site of relapse is rare. Two infants with poor-prognosis stage IV neuroblastoma presented early after high-dose therapy and autologous bone marrow transplant with isolated spinal relapse heralded by misleading symptoms. The rarity of such isolated relapses is reviewed, and an etiologic hypothesis is proposed.
神经母细胞瘤可能因胸腹部病变呈哑铃状延伸而导致脊髓受压。孤立性脊髓受累作为唯一的复发部位很罕见。两名预后不良的IV期神经母细胞瘤婴儿在大剂量治疗和自体骨髓移植后早期出现，以误导性症状为先兆的孤立性脊髓复发。本文回顾了这种孤立性复发的罕见情况，并提出了一个病因假说。
