Suzuki J, Yoshikawa N, Nakamura H
Department of Paediatrics, Kobe University Hospital, Japan.
Pediatr Nephrol. 1994 Aug;8(4):416-9. doi: 10.1007/BF00856517.
Quantitative analysis of the glomerular area, mesangial matrix and mesangial cells was performed using renal biopsy specimens from 22 children with focal segmental glomerulosclerosis (FSGS) and 20 with minimal change nephrotic syndrome (MCNS). Non-sclerotic glomeruli were examined. All children in both groups showed nephrotic syndrome at the time of biopsy. Children with benign haematuria were examined as controls. Glomerular area increased with age in the FSGS, MCNS and control groups. The glomerular area was significantly greater in FSGS (1.5 +/- 0.4 x 10(4) microns 2) than in MCNS (1.2 +/- 0.2 x 10(4) microns 2) or in controls (1.2 +/- 0.3 x 10(4) microns 2) (P < 0.05). Mesangial matrix was increased with age in the three groups. The mesangial matrix was significantly increased in FSGS (28.3 +/- 4.0%; mesangial matrix area/glomerular area) compared with MCNS (24.9 +/- 4.1%) and controls (23.0 +/- 3.0%) (P < 0.01). These findings suggest that both glomerular hypertrophy and mesangial matrix increase in non-sclerotic glomeruli in FSGS may lead to glomerular sclerosis.
对22例局灶节段性肾小球硬化（FSGS）患儿和20例微小病变肾病综合征（MCNS）患儿的肾活检标本进行肾小球面积、系膜基质和系膜细胞的定量分析。检查非硬化性肾小球。两组所有患儿在活检时均表现为肾病综合征。以良性血尿患儿作为对照。FSGS组、MCNS组和对照组的肾小球面积均随年龄增加。FSGS组的肾小球面积（1.5±0.4×10⁴平方微米）显著大于MCNS组（1.2±0.2×10⁴平方微米）或对照组（1.2±0.3×10⁴平方微米）（P<0.05）。三组的系膜基质均随年龄增加。与MCNS组（24.9±4.1%）和对照组（23.0±3.0%）相比，FSGS组的系膜基质显著增加（28.3±4.0%；系膜基质面积/肾小球面积）（P<0.01）。这些发现提示，FSGS中非硬化性肾小球的肾小球肥大和系膜基质增加均可能导致肾小球硬化。
