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二甲基亚砜(DMSO)对二倍体酵母辐射诱导的杂合等位基因回复突变的影响。

Effect of dimethyl sulfoxide (DMSO) on radiation-induced heteroallelic reversion in diploid yeast.

作者信息

Singh D R, Mahajan J M, Krishnan D

出版信息

Mutat Res. 1976 Nov;37(2-3):193-200. doi: 10.1016/0027-5107(76)90033-6.

DOI:10.1016/0027-5107(76)90033-6
PMID:794705
Abstract

Dimethyl sulfoxide has cryoprotective and radioprotective properties. It is also an efficient scavenger of radicals produced by raiolysis of water. Gamma-induced reversions of diploid yeast in the presence of this chemical during irradiation have been studied. The dose-modifying factor was in the same range as for survival. When the yeast was irradiated in the frozen state the observed protection by DMSO disappeared. The results are discussed in terms of direct and indirect actions of radiations and the radical-scavenging ability of this chemical.

摘要

二甲基亚砜具有冷冻保护和辐射保护特性。它还是水的辐射分解产生的自由基的高效清除剂。已经研究了在辐照期间这种化学物质存在下γ射线诱导的二倍体酵母回复突变。剂量修正因子与存活率处于相同范围。当酵母在冷冻状态下辐照时,观察到的二甲基亚砜的保护作用消失。根据辐射的直接和间接作用以及这种化学物质的自由基清除能力对结果进行了讨论。

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