Nichols P H, Ward U, Ramsden C W, Primrose J N
Department of Clinical Medicine, St James's University Hospital, Leeds, UK.
Br J Cancer. 1994 Nov;70(5):946-9. doi: 10.1038/bjc.1994.426.
Interferon alpha (IFN-alpha) enhances the activity of 5-fluorouracil (5-FU) in the treatment of advanced colorectal cancer although the mechanism is not understood. We have investigated the effect of this combination on cellular immunity and compared this with standard therapy of 5-FU/L-leucovorin, in 24 patients with advanced colorectal cancer. This study has demonstrated an enhancement of the cellular immune response in patients given 5-FU/IFN-alpha with augmentation of natural killer (NK) cell function and abrogation of 5-FU-induced suppression of lymphokine-activated killer (LAK) cell activity.
α干扰素（IFN-α）可增强5-氟尿嘧啶（5-FU）治疗晚期结直肠癌的活性，但其机制尚不清楚。我们研究了这种联合用药对细胞免疫的影响，并将其与24例晚期结直肠癌患者接受的5-FU/亚叶酸钙标准疗法进行了比较。本研究表明，接受5-FU/IFN-α治疗的患者细胞免疫反应增强，自然杀伤（NK）细胞功能增强，5-FU诱导的淋巴因子激活杀伤（LAK）细胞活性抑制被消除。
