Okamoto H, Fukuda A, Mizuno K, Matsuyoshi N, Fujii K, Imamura S
Department of Dermatology, Faculty of Medicine, Kyoto University, Japan.
Photodermatol Photoimmunol Photomed. 1994 Jun;10(3):134-6.
Reactivation of a solar burn has been reported after administration of methotrexate for cancer and psoriasis patients. We report a case of psoriasis with a similar but delayed elicitation of phototoxic reaction by administration of low-dose methotrexate one month after psoralen and long-wave ultraviolet light (PUVA) treatment. The reactivation was seen in an already receding phototoxicity test area but not in a less phototoxic, noninterval PUVA treated area, suggesting that the reactivation by methotrexate is related with the severity of light-induced skin inflammation.
据报道，癌症和银屑病患者在使用甲氨蝶呤后出现了晒伤复发的情况。我们报告了一例银屑病患者，在补骨脂素和长波紫外线（PUVA）治疗一个月后，通过给予低剂量甲氨蝶呤引发了类似但延迟的光毒性反应。这种再激活现象出现在已经消退的光毒性试验区域，而在光毒性较小、非间隔性PUVA治疗的区域未出现，这表明甲氨蝶呤引发的再激活与光诱导的皮肤炎症严重程度有关。
