Armstrong R B, Poh-Fitzpatrick M B
Arch Dermatol. 1982 Mar;118(3):177-8.
Reactivation of a sunburn has been reported after the administration of methotrexate for cancer chemotherapy. A similar reaction is described in a patient with psoriasis who was receiving both coal tar with ultraviolet radiation for cutaneous lesions and methotrexate for arthritis. Knowledge of this poorly understood side effect of methotrexate is particularly important for physicians administering phototherapy and, perhaps, photochemotherapy.
据报道，在使用甲氨蝶呤进行癌症化疗后出现了晒伤复发的情况。一名银屑病患者也出现了类似反应，该患者正在接受煤焦油联合紫外线治疗皮肤损伤，同时接受甲氨蝶呤治疗关节炎。对于进行光疗以及可能进行光化学疗法的医生来说，了解甲氨蝶呤这种鲜为人知的副作用尤为重要。
