一种水溶性补体激活聚丙烯酸-IgG聚合物的合成。
The synthesis of a water soluble complement activating polyacrylic acid-IgG polymer.
作者信息
Schmer G, Henderson R A, Müller W
机构信息
Department of Laboratory Medicine, University of Washington, Seattle 98195.
出版信息
J Biomater Sci Polym Ed. 1994;6(1):67-78. doi: 10.1163/156856295x00760.
PMID:7947474
Abstract
Polyacrylic acid-IgG polymer (PAA-IgG) activates the classical and alternative pathway of complement as shown by specific Clq-(IgG-PAA) interaction and the generation of C4d, Bb, C3b, C3a and C5a. This water soluble and stable PAA-IgG polymer represents a model substance for the study of humoral and cellular inflammatory mechanisms, mediated by the complement system.
摘要
聚丙烯酸-IgG聚合物（PAA-IgG）可激活补体的经典途径和替代途径，如特异性Clq-（IgG-PAA）相互作用以及C4d、Bb、C3b、C3a和C5a的生成所示。这种水溶性且稳定的PAA-IgG聚合物代表了一种用于研究由补体系统介导的体液和细胞炎症机制的模型物质。
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