el-Refaey H, Templeton A
Department of Obstetrics and Gynaecology, University of Aberdeen.
Br J Obstet Gynaecol. 1994 Sep;101(9):792-6. doi: 10.1111/j.1471-0528.1994.tb11948.x.
A randomised study of 150 women of 56 days gestation, or less, allocated to receive oral misoprostol either in a single dose of 800 micrograms or as two doses of 400 micrograms administered sequentially 2 h apart; in each case misoprostol was administered 36 to 48 h after receiving mifepristone 200 mg orally.
Complete abortion rates, the frequency and severity (patients' perception) of gastrointestinal side effects, and blood pressure changes in response to prostaglandin administration.
The overall success rate was 93%. Seventy-one (95%) women who received a single dose of misoprostol and sixty-nine (92%) who received the sequential dose aborted completely. There were two ongoing pregnancies in the first group (2.5%) and three (4%) in the second. The overall ongoing pregnancy rate was 3%. The incidence of diarrhoea was significantly lower for women receiving the sequential dose, and no significant differences were found in the incidence of the other gastrointestinal side effects. The only noted significant change in blood pressure was in diastolic pressure 4 h after the administration of the higher dose of prostaglandin, but this was slight.
The combination of mifepristone and oral misoprostol provides an alternative method to inducing abortion of pregnancies of up to eight weeks gestation. Patients receiving the single dose of 800 micrograms were more troubled by diarrhoea than those on the sequential regimen. The ongoing pregnancy rate was higher than previously reported with vaginal or parenteral administration of prostaglandin.
一项对150名妊娠56天及以内的女性进行的随机研究，这些女性被分配接受单剂量800微克口服米索前列醇，或分两剂，每剂400微克，间隔2小时依次给药；在每种情况下，米索前列醇均在口服200毫克米非司酮36至48小时后给药。
完全流产率、胃肠道副作用的频率和严重程度（患者感受）以及前列腺素给药后的血压变化。
总体成功率为93%。接受单剂量米索前列醇的71名（95%）女性和接受序贯给药的69名（92%）女性完全流产。第一组有2例（2.5%）持续妊娠，第二组有3例（4%）。总体持续妊娠率为3%。接受序贯给药的女性腹泻发生率显著较低，其他胃肠道副作用的发生率未发现显著差异。唯一观察到的显著血压变化是在给予高剂量前列腺素后4小时舒张压有轻微变化。
米非司酮与口服米索前列醇联合使用为妊娠8周及以内的引产提供了一种替代方法。接受800微克单剂量的患者比接受序贯给药方案的患者腹泻困扰更大。持续妊娠率高于先前报道的阴道或胃肠外给予前列腺素的情况。
