Soustek Z
Department of Pathology, Mental Hospital Dobrany, Czech Republic.
Zentralbl Pathol. 1994 Jul;140(2):143-8.
In 10 cases of senile dementia of Alzheimer's type (AD) a systematic post-mortem ultrastructural analysis was performed. Attention was paid mainly to the presence of autolysosomes in the neuropil of the brain cortex. Autolysosomes appeared as osmiophilic dense bodies (DB) which originated in synaptic terminals and peripheral nerve-cell processes. DBs contained sequestrated cellular material wrapped by pinched off, invaginated cell membrane. DB were very frequent also in fields where no senile plaques (SP) and/or nerve-cell processes with paired helical filaments (PHF) were present. Abnormal fermentative degradation of DBs and their possible negative influence on the plasmatic flow in nerve-cell processes is discussed.
对10例阿尔茨海默型老年痴呆症（AD）患者进行了系统的死后超微结构分析。主要关注大脑皮质神经毡中自噬溶酶体的存在情况。自噬溶酶体表现为嗜锇致密小体（DB），起源于突触终末和周围神经细胞突起。DB包含被挤压、内陷细胞膜包裹的隔离细胞物质。在没有老年斑（SP）和/或带有双螺旋丝（PHF）的神经细胞突起的区域，DB也非常常见。讨论了DB的异常发酵降解及其对神经细胞突起中血浆流动可能产生的负面影响。
