Scheff S W, Sparks L, Price D A
Sanders-Brown Center on Aging, University of Kentucky, Lexington 40536-0230.
Ann Neurol. 1993 Sep;34(3):356-61. doi: 10.1002/ana.410340309.
We quantified the synaptic density in the entorhinal cortex (Brodmann area 28) in autopsy material from 10 individuals with Alzheimer's disease and compared them to 11 age-matched, postmortem-matched control subjects without dementia, using standard electron microscopy. The statistical data showed no change in synaptic density between control and Alzheimer subjects, in either lamina III or V of the cortex. There were no correlations between synaptic density and synaptic apposition length or density of senile plaques. The entorhinal cortex stands in marked contrast to other cortical areas that show a significant decline in synaptic numbers with Alzheimer's disease. This preservation of synaptic numbers may be related to a plasticity response that is greater in the entorhinal area than in other areas of the cortex.
我们使用标准电子显微镜，对10例阿尔茨海默病患者尸检材料内嗅皮质（布罗德曼28区）的突触密度进行了量化，并将其与11名年龄匹配、死后匹配且无痴呆的对照受试者进行比较。统计数据显示，在皮质的Ⅲ层或Ⅴ层，对照组和阿尔茨海默病患者之间的突触密度没有变化。突触密度与突触并置长度或老年斑密度之间没有相关性。内嗅皮质与其他皮质区域形成显著对比，后者在阿尔茨海默病中显示突触数量显著下降。突触数量的这种保留可能与内嗅区比皮质其他区域更大的可塑性反应有关。
