Wigley R A, Fowles M
N Z Med J. 1976 Aug 11;84(569):104-10.
A review of the literature on the gastrointestinal side effects of the analgesic drugs has disclosed a disparity between generally held views and the scientific evidence. This is largely due to the paucity of large long term controlled trials since the cost of these is very high. The problems in mounting a large observational study with population controls are discussed against a backgrwound of exploratory work in Australia and New Zealand and the conclusion is reached that a comprehensive survey is needed. The difficulties in mounting such a survey are discussed.
对镇痛药胃肠道副作用的文献综述揭示了普遍观点与科学证据之间的差异。这主要是由于大型长期对照试验数量稀少，因为其成本非常高。在澳大利亚和新西兰探索性工作的背景下，讨论了开展有群体对照的大型观察性研究的问题，并得出需要进行全面调查的结论。还讨论了开展此类调查的困难。
