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ABFI对酿酒酵母ARS1 B结构域的染色质组织有贡献。

ABFI contributes to the chromatin organization of Saccharomyces cerevisiae ARS1 B-domain.

作者信息

Venditti P, Costanzo G, Negri R, Camilloni G

机构信息

Centro di Studio per gli Acidi Nucleici, CNR, Rome, Italy.

出版信息

Biochim Biophys Acta. 1994 Nov 22;1219(3):677-89. doi: 10.1016/0167-4781(94)90227-5.

DOI:10.1016/0167-4781(94)90227-5
PMID:7948025
Abstract

The involvement of the ABFI transcription factor in organizing the chromatin structure of the Saccharomyces cerevisiae ARS1 region has been previously postulated. We studied the ARS1 chromatin structure both on the chromosome and on plasmids carrying wild type or mutated ABFI binding sites, using a recently developed no-background technique for nucleosome mapping, coupled with high resolution micrococcal nuclease in vivo footprinting. We show that ABFI protein acts as a boundary element of chromatin structure, by limiting the invasion by nucleosomes toward the essential A-domain.

摘要

先前曾推测ABFI转录因子参与酿酒酵母ARS1区域染色质结构的组织。我们使用最近开发的无背景核小体定位技术，并结合体内高分辨率微球菌核酸酶足迹分析，研究了染色体上以及携带野生型或突变型ABFI结合位点的质粒上的ARS1染色质结构。我们发现，ABFI蛋白通过限制核小体向必需A结构域的侵入，充当染色质结构的边界元件。

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ABFI contributes to the chromatin organization of Saccharomyces cerevisiae ARS1 B-domain.ABFI对酿酒酵母ARS1 B结构域的染色质组织有贡献。
Biochim Biophys Acta. 1994 Nov 22;1219(3):677-89. doi: 10.1016/0167-4781(94)90227-5.
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A yeast ARS-binding protein activates transcription synergistically in combination with other weak activating factors.一种酵母ARS结合蛋白与其他弱激活因子协同激活转录。
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ARS binding factor I of the yeast Saccharomyces cerevisiae binds to sequences in telomeric and nontelomeric autonomously replicating sequences.酿酒酵母的ARS结合因子I与端粒和非端粒自主复制序列中的序列结合。
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