Paweletz N, Boxberger H J
Growth and Division of the Cell/0430, German Cancer Research Center, Heidelberg.
Crit Rev Oncog. 1994;5(1):69-105. doi: 10.1615/critrevoncog.v5.i1.40.
Analyzing the different steps of malignant growth (primary tumor, metastasizing tumor cells, secondary tumor), one recognizes an intense interaction between normal and malignant cells. Tumor cells not only induce activities of normal cells, which normally are rarely activated, but also they exploit properties of normal cells for their own purposes. The major mechanisms and processes of this "parasitism" are described in more detail and the results are discussed. Tumors cannot grow beyond a certain size without a supply of blood and lymph vessels by the host (angiogenesis). Metastasizing tumor cells cannot leave the vessel (extravasate) in which they are transported without the cooperation of the respective endothelial cells of the host. An appropriate environment formed by the host tissues is essential for the settlement of tumor cells at secondary sites. Historically, these are a few examples that show intense cooperation between host and tumor. More are given in the present contribution.
分析恶性生长的不同阶段（原发性肿瘤、转移肿瘤细胞、继发性肿瘤），人们会认识到正常细胞与恶性细胞之间存在着强烈的相互作用。肿瘤细胞不仅能诱导正常细胞的活动，而这些活动在正常情况下很少被激活，而且它们还会为自身目的利用正常细胞的特性。本文将更详细地描述这种“寄生”的主要机制和过程，并讨论其结果。肿瘤如果没有宿主提供的血液和淋巴管供应（血管生成），就无法生长到一定大小。转移的肿瘤细胞如果没有宿主相应内皮细胞的合作，就无法离开它们所运输的血管（外渗）。宿主组织形成的适宜环境对于肿瘤细胞在继发性位点的定植至关重要。从历史上看，这些只是少数几个显示宿主与肿瘤之间密切合作的例子。本论文中还给出了更多例子。
