The role of the extracellular matrix in tumor cell metastasis.

The extracellular matrix is a macromolecular network that surrounds cells and makes up a significant portion of their microenvironment. During the processes of invasion and metastasis, tumor cells encounter interstitial stroma and basement membranes many times. In fact, tumor cell response to extracellular matrix components appears to be a major determinant of metastatic potential.