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Detection of prion protein in formalin-fixed brain by hydrated autoclaving immunohistochemistry for the diagnosis of scrapie in sheep.

作者信息

Miller J M, Jenny A L, Taylor W D, Race R E, Ernst D R, Katz J B, Rubenstein R

机构信息

Virology Cattle Research Unit, National Animal Disease Center, USDA, Ames, IA 50010.

出版信息

J Vet Diagn Invest. 1994 Jul;6(3):366-8. doi: 10.1177/104063879400600315.

DOI:10.1177/104063879400600315
PMID:7948209
Abstract
摘要

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Failure to detect abnormal prion protein and scrapie-associated fibrils 6 wk after intracerebral inoculation of genetically susceptible sheep with scrapie agent.在用瘙痒病病原体对基因易感性绵羊进行脑内接种6周后,未能检测到异常朊病毒蛋白和瘙痒病相关纤维。
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