Rey M, Segerer H, Kiessling C, Obladen M
Abteilung Neonatalogie, Universitätsklinikum Rudolf Virchow, Freie Universität Berlin, Deutschland.
Biol Neonate. 1994;66(1):16-21. doi: 10.1159/000244085.
Fifteen preterm infants suffering from respiratory distress syndrome were randomly allocated to receive either high-dose (200 mg/kg) or low-dose (100 mg/kg) surfactant treatment. Retreatments were done with the low dose. Blood pressure, blood gases and cerebral blood flow velocities were determined before and after 24 bolus instillations. With the high dose mean blood pressure and mean cerebral blood flow velocity dropped significantly. With the low dose only mean cerebral blood flow velocity decreased; the course was unrelated to blood pressure or PCO2 fluctuations. The mechanisms leading to the observed circulatory changes after surfactant instillation remain unclear.
15名患有呼吸窘迫综合征的早产儿被随机分配接受高剂量（200毫克/千克）或低剂量（100毫克/千克）的表面活性剂治疗。低剂量用于再次治疗。在24次推注给药前后测定血压、血气和脑血流速度。高剂量组平均血压和平均脑血流速度显著下降。低剂量组仅平均脑血流速度降低；其过程与血压或二氧化碳分压波动无关。表面活性剂滴注后导致观察到的循环变化的机制仍不清楚。
