Losonsky G A, Wolf A, Schwalbe R S, Nataro J, Gibson C B, Lewis E W
Division of Pediatric Infectious Diseases and Tropical Pediatrics, University of Maryland School of Medicine, Baltimore 21201.
Clin Infect Dis. 1994 Jul;19(1):163-5. doi: 10.1093/clinids/19.1.163.
Following neurosurgery necessitated by intractable seizures, Enterococcus faecium meningitis that was resistant to ampicillin, a high-level aminoglycoside (MIC, > 2,000 micrograms/mL), and vancomycin developed in a 6-year-old boy. Treatment with intrathecal teicoplanin in combination with intravenous clindamycin, rifampin, and ampicillin was successful. The role of intravenous and intrathecal antibiotics in treatment of this infection is discussed. This case is illustrative of the safety and potential usefulness of intrathecally administered teicoplanin.
一名6岁男孩因顽固性癫痫接受神经外科手术后，发生了对氨苄西林、高水平氨基糖苷类药物（最低抑菌浓度，>2000微克/毫升）和万古霉素耐药的粪肠球菌脑膜炎。鞘内注射替考拉宁联合静脉注射克林霉素、利福平和氨苄西林治疗成功。讨论了静脉和鞘内抗生素在这种感染治疗中的作用。该病例说明了鞘内注射替考拉宁的安全性和潜在效用。
