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1
Treatment of enterococcal pyelonephritis with trovafloxacin and rifampin: in vitro-in vivo contrast.曲伐沙星与利福平治疗肠球菌性肾盂肾炎：体外-体内对比
Antimicrob Agents Chemother. 1998 Jan;42(1):188-9. doi: 10.1128/AAC.42.1.188.
2
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Antimicrob Agents Chemother. 1981 Oct;20(4):491-2. doi: 10.1128/AAC.20.4.491.
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本文引用的文献

1
Pyelonephritis. I. Observations on the course of chronic non-obstructed enterococcal infection in the kidnev of the rat.肾盂肾炎。一、大鼠肾脏慢性非梗阻性肠球菌感染病程的观察
Yale J Biol Med. 1961 Apr;33(5):372-85.
2
In vitro activity of the combination of trovafloxacin and other antibiotics against enterococci.曲伐沙星与其他抗生素联合对肠球菌的体外活性
Diagn Microbiol Infect Dis. 1997 Dec;29(4):233-9. doi: 10.1016/s0732-8893(97)00161-2.
3
Pharmacokinetics of trovafloxacin (CP-99,219), a new quinolone, in rats, dogs, and monkeys.新型喹诺酮类药物曲伐沙星（CP-99,219）在大鼠、犬和猴体内的药代动力学。
Antimicrob Agents Chemother. 1996 Mar;40(3):561-6. doi: 10.1128/AAC.40.3.561.
4
In vitro activity of CP-99,219, a new fluoroquinolone, against clinical isolates of gram-positive bacteria.新型氟喹诺酮类药物CP-99,219对革兰氏阳性菌临床分离株的体外活性
Antimicrob Agents Chemother. 1993 Feb;37(2):366-70. doi: 10.1128/AAC.37.2.366.
5
In vitro antimicrobial activity of CP-99,219, a novel azabicyclo-naphthyridone.新型氮杂双环萘啶酮CP-99,219的体外抗菌活性
Antimicrob Agents Chemother. 1993 Feb;37(2):349-53. doi: 10.1128/AAC.37.2.349.
6
Successful treatment of meningitis due to multiply resistant Enterococcus faecium with a combination of intrathecal teicoplanin and intravenous antimicrobial agents.鞘内注射替考拉宁与静脉抗菌药物联合成功治疗多重耐药屎肠球菌引起的脑膜炎。
Clin Infect Dis. 1994 Jul;19(1):163-5. doi: 10.1093/clinids/19.1.163.
7
Pyelonephritis. XII. Comparison of penicillin, ampicillin, and streptomycin in enterococcal infection in rats.
J Infect Dis. 1971 Jun;123(6):611-7. doi: 10.1093/infdis/123.6.611.
8
Treatment of methicillin-resistant Staphylococcus aureus experimental osteomyelitis with ciprofloxacin or vancomycin alone or in combination with rifampin.单用环丙沙星或万古霉素，或联合利福平治疗耐甲氧西林金黄色葡萄球菌实验性骨髓炎。
Am J Med. 1987 Apr 27;82(4A):73-5.
9
Hospital-acquired infection with vancomycin-resistant Enterococcus faecium transmitted by electronic thermometers.由电子体温计传播的耐万古霉素屎肠球菌医院获得性感染。
Ann Intern Med. 1992 Jul 15;117(2):112-6. doi: 10.7326/0003-4819-117-2-112.

曲伐沙星与利福平治疗肠球菌性肾盂肾炎：体外-体内对比

Treatment of enterococcal pyelonephritis with trovafloxacin and rifampin: in vitro-in vivo contrast.

作者信息

Montgomerie J Z, Schick D G

机构信息

Department of Medicine, Rancho Los Amigos Medical Center, Downey, California 90242, USA.

出版信息

Antimicrob Agents Chemother. 1998 Jan;42(1):188-9. doi: 10.1128/AAC.42.1.188.

DOI:10.1128/AAC.42.1.188
PMID:9449285
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC105480/
Abstract

The in vitro bactericidal interaction of trovafloxacin and rifampin against Enterococcus spp. has indicated that antagonism occurs between these two antimicrobial agents. This drug combination was examined in vivo in rats with experimental pyelonephritis. The rats received trovafloxacin, rifampin, or both drugs. On the basis of the mean log10 CFU of Enterococcus faecalis from the kidneys, there was no evidence that trovafloxacin and rifampin were antagonistic in vivo.

摘要

曲伐沙星与利福平对肠球菌属的体外杀菌相互作用表明，这两种抗菌药物之间存在拮抗作用。在患有实验性肾盂肾炎的大鼠体内对这种药物组合进行了研究。大鼠接受曲伐沙星、利福平或两种药物。根据来自肾脏的粪肠球菌的平均log10 CFU，没有证据表明曲伐沙星和利福平在体内具有拮抗作用。