曲伐沙星与利福平治疗肠球菌性肾盂肾炎：体外-体内对比
Treatment of enterococcal pyelonephritis with trovafloxacin and rifampin: in vitro-in vivo contrast.
作者信息
Montgomerie J Z, Schick D G
机构信息
Department of Medicine, Rancho Los Amigos Medical Center, Downey, California 90242, USA.
出版信息
Antimicrob Agents Chemother. 1998 Jan;42(1):188-9. doi: 10.1128/AAC.42.1.188.
Abstract
The in vitro bactericidal interaction of trovafloxacin and rifampin against Enterococcus spp. has indicated that antagonism occurs between these two antimicrobial agents. This drug combination was examined in vivo in rats with experimental pyelonephritis. The rats received trovafloxacin, rifampin, or both drugs. On the basis of the mean log10 CFU of Enterococcus faecalis from the kidneys, there was no evidence that trovafloxacin and rifampin were antagonistic in vivo.
摘要
曲伐沙星与利福平对肠球菌属的体外杀菌相互作用表明，这两种抗菌药物之间存在拮抗作用。在患有实验性肾盂肾炎的大鼠体内对这种药物组合进行了研究。大鼠接受曲伐沙星、利福平或两种药物。根据来自肾脏的粪肠球菌的平均log10 CFU，没有证据表明曲伐沙星和利福平在体内具有拮抗作用。
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