García O, Trigo R M, Blanco M D, Teijón J M
Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad Complutense de Madrid, Spain.
Biomaterials. 1994 Jul;15(9):689-94. doi: 10.1016/0142-9612(94)90167-8.
Controlled release of 5-fluorouracil (5-FU) from poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels with three different degrees of crosslinking is reported. The swelling kinetic of PHEMA hydrogels in water was studied at different disc thicknesses and temperatures, and the diffusion coefficient and activation energy of the process were obtained. The gels were loaded with 5-FU by immersing them in concentrated aqueous solutions of the drug. The 5-FU release was studied as a function of temperature, disc thickness, disc load and degree of crosslinking of the gels; the diffusion coefficient and activation energy of the release process were also obtained.
报道了5-氟尿嘧啶（5-FU）从具有三种不同交联度的聚甲基丙烯酸2-羟乙酯（PHEMA）水凝胶中的控释情况。研究了不同圆盘厚度和温度下PHEMA水凝胶在水中的溶胀动力学，并获得了该过程的扩散系数和活化能。通过将凝胶浸泡在药物的浓水溶液中来负载5-FU。研究了5-FU释放随温度、圆盘厚度、圆盘负载和凝胶交联度的变化情况；还获得了释放过程的扩散系数和活化能。
